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«European Journal of Molecular Biotechnology» - scientific journal.

E-ISSN 2409-1332

Publication frequency – once a year.
Issued from 2013.

1 June 27, 2018

Articles and Statements

1. Abdelilah Benallou, Habib El Alaoui El Abdallaoui, Hocine Garmes
An Investigation of the Reason of not Feasibility of Hetero-Diels-Alder Reaction of Isoselenazole with Unsymmetrical Acetylenic Dienophile: A Conceptual DFT Study and Topological Analysis of ELF Function

European Journal of Molecular Biotechnology, 2018, 6(1): 3-15.
DOI: 10.13187/ejmb.2018.1.3CrossRef

A detailed mechanistic study by molecular electron density of the Hetero-Diels-Alder (HDA) reaction of isoselenazole with unsymmetrical acetylenic dienophile is carried out. The high activation energy involved in the transition state of both Ortho and Meta cycloadduct implies that this reaction may not possible, even in the presence of solvent toluene. Besides, ELF shows that the not formation of the basin at the N2 nitrogen atom of isoselenazole moiety. Therefore, the negligible charge transfer between reagents and the large electron density attracted by the lone pair at the N2 atom, in addition to the C1SeN2 fragment distortion energy cost, they are not allowing the formation of the radicals (basins) necessary at the most significant atoms, these factors are probably responsible for the highest barrier activation.

URL: http://ejournal8.com/journals_n/1530699897.pdf
Number of views: 1212      Download in PDF

2. Abdelilah Benallou, Habib El Alaoui El Abdallaoui, Hocine Garmes
The Contribution to Bonding by Lone Pairs in the Hydrogen Transfer of Adenine Tautomerization (3H→9H) in the First Excited Electronic State: ELF Analysis

European Journal of Molecular Biotechnology, 2018, 6(1): 16-24.
DOI: 10.13187/ejmb.2018.1.16CrossRef

The hydrogen transfer of adenine tautomerization (3H→9H) is performed by using ELF topological analysis, this study has been carried out at TD-DFT method with B3LYP and 6-311G++(d,p) basis set. Our investigation leads us to conclude that lone pairs electrons of nucleophilic nitrogen atom are not a non bonding electrons, although the lone pairs may contribute to the covalently bond with an electrophile (H atom) behind TS (second phase), whereas excited electrons are highly contributed to the first phase before TS location, the contribution to bonding by lone pairs is depending generally on the evolution of chemical structure along IRC. Therefore, lone pairs electron are considerably helped for hydrogen transfer of adenine tautomerization in the first electronic state. Subsequently, lone pairs and non bonding electrons are not strictly equivalent to each other.

URL: http://ejournal8.com/journals_n/1530699962.pdf
Number of views: 1220      Download in PDF

3. Ignat Ignatov, Yuliana Pesheva
Rhodopsin. Bacteriorhodopsin in Biotechnology. Electromagnetic Conception for the Eyesight

European Journal of Molecular Biotechnology, 2018, 6(1): 25-40.
DOI: 10.13187/ejmb.2018.1.25CrossRef

This review article views predominately the structure and function of animal and bacterial photoreceptor pigments (rhodopsin, iodopsin, bacteriorhodopsin) and their aspects of nano- and biotechnological usage. On an example of bacteriorhodopsin is described the method of its isolation from purple membranes of photo-organotrophic halobacterium Halobacterium halobium by cellular autolysis by distilled water, processing of bacterial biomass by ultrasound at 22 KHz, alcohol extraction of low and high-weight molecular impurities, cellular RNA, carotenoids and lipids, the solubilization with 0,5 % (w/v) SDS-Na and subsequent fractionation by methanol and gel filtration chromatography on Sephadex G-200 Column balanced with 0.09 M Tris-borate buffer (pH = 8,35) with 0,1 % (w/v) SDS-Na and 2,5 mM EDTA. Within the framework of the research the mechanism of color perception by the visual analyzer having the ability to analyze certain ranges of the optical spectrum, as colors was studied along with an analysis of the additive mixing of two colors. It was shown that at the mixing of electromagnetic waves with different wavelengths, the visual analyzer perceive them as separate or average wave length corresponding to mix colors (Marinov, Ignatov, 2008).

URL: http://ejournal8.com/journals_n/1530700026.pdf
Number of views: 1250      Download in PDF

4. Ignat Ignatov, Yuliana Pesheva
ZEOLITH Detox for Detoxification of Human Body. Proofs for Anti Inflammatory Effects of Zeolite and Detoxification

European Journal of Molecular Biotechnology, 2018, 6(1): 41-52.
DOI: 10.13187/ejmb.2018.1.41CrossRef

We studied the mathematical model of interaction with water of natural mineral and microporous crystalline mineral ZEOLITH detox of LavaVitae Company (Austria). In this report are submitted data about the interaction of ZEOLITH detox with water, obtained by non-equilibrium (NES) and differential-equilibrium energy spectrum (DNES) of water. The average energy (ΔEH... O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of ZEOLITH detox with water measured by NES- and DNES-methods is ΔE=-0.0034±0.0011 eV for ZEOLITH detox. The average energy (ΔEH... O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of ZEOLITH detox with water measured by NES- and DNES-methods is ΔE=-0.0034±0.0011 eV for ZEOLITH detox. The average energy (ΔEH... O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of ZEOLITH detox with water measured by NES- and DNES-methods. These results suggest the restructuring of ΔEH... O values among H2O molecules with a statistically reliable increase of local extremums in DNES-spectra. The research is performed for ZEOLITH detox with study of pH and oxidative reduction potential (ORP). The report shows the effects of zeolite for the detoxification of human body. The inflammations are one of the basic reasons for aging process. In this research we show anti inflammatory effects from ZEOLITH detox.

URL: http://ejournal8.com/journals_n/1530700085.pdf
Number of views: 1215      Download in PDF

5. Elena A. Ivantsova, Nikolay V. Onistratenko, Nadezhda V. German, Pavel A. Krylov, Anna A. Tikhonova, Valery V. Novochadov
Targered Changes in the Natural and Semi-Artificial Arid Phytocenoses in the Contact Zone with the Agrocenoses: A System Control Model-Based Approach

European Journal of Molecular Biotechnology, 2018, 6(1): 53-60.
DOI: 10.13187/ejmb.2018.1.53CrossRef

The article presents the results of the study to analyze the plant and microbial soil associations in the composition of agrocenoses, natural steppe biocenoses and territorially integral areas of grasses on the border or within agrocenoses, mainly anthropogenic origin, named in the article as ‘intrusions’. We show the key relationships between the main participants (47 plant species and 24 species of soil microorganisms, ranked by number in the association) in concurrence for the assimilation of soil trace elements. On the basis of data on the number, main phenological characteristics of plants and microorganisms, as well as the content of manganese, nickel, copper and zinc in the soil, the main consort bonds in this biosystem were identified. The analysis of the general influence of concrete intrusions on the adjacent agrocenosis made it possible to identify trace elements and types of soil microorganisms, which increase helped to limit the negative impact of intrusions. The obtained data can be used to form biotechnologies for optimization of agrocenoses in the conditions of the arid zone.

URL: http://ejournal8.com/journals_n/1530700161.pdf
Number of views: 1191      Download in PDF

6. I.A.A. Ibrahim, M.M. Mohammad, A. A. Faisal, H. Musa
Bioactivity of Crude Extracts of Stem Bark of Vetillaria Paradoxa

European Journal of Molecular Biotechnology, 2018, 6(1): 61-66.
DOI: 10.13187/ejmb.2018.1.61CrossRef

This research aimed to study the bioactivity of crude extracts of stem bark of Vetillaria paradoxa“Shea-nut tree” as used in traditional medicine for treatment of stomach ache and control of diarrhea, using Hexane, Acetone and Ethanol as the extraction solvents. Phytochemical screening of stem bark of extracts of Vitellaria paradoxa revealed the presence of alkaloids, steroids, phenolic compounds, flavonoids, Saponins, tannins, and cardiac glycosides. Ethanol, acetone, and hexane extracts inhibited the growth of pathogenic Escherichia coli, salmonella typhi, and stapilycoccus aureus with varying degrees of activity with the ehanol extract demonstrating the highest activity against all the tested bacterial organisms.

URL: http://ejournal8.com/journals_n/1530700232.pdf
Number of views: 1231      Download in PDF

full number
URL: http://ejournal8.com/journals_n/1530700290.pdf
Number of views: 1251      Download in PDF

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