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«European Journal of Molecular Biotechnology» (Европейский журнал молекулярной биотехнологии) – научный журнал.

E-ISSN 2409-1332

Периодичность – 2 раза в год.
Издается с 2013 года.

2 December 29, 2019


1. Ahmad H. Al-Humairi
Modern Nanomaterials and Nanotechnology in Diagnosis and Treatment of Malignant Tumors of Gastrointestinal Tract

European Journal of Molecular Biotechnology, 2019, 7(2): 49-62.
DOI: 10.13187/ejmb.2019.2.49CrossRef

This review aims to systematize current achievements in the use of nanotechnology for the detection, diagnosis, treatment and prognosis of gastrointestinal (GI) malignant tumors. Information about the use of nanovesicles isolated from the body (exosomes) and synthesized (liposomes) for targeted delivery of drugs and imaging agents to cancer cells for this purpose is presented. A separate section of the review deals with revealing the laws of transport and interaction of nanoparticles with tumor cells to diagnose and treat GI malignant tumors. Here we present modern research to determine the effectiveness of micelles, liposomes, solid lipid nanoparticles, mesoporous silica nanoparticles and particles containing perfluorocarbon. The problems and achievements in the use of nanoparticles for targeted delivery of chemotherapy drugs to cancer cells using ultrasound are considered. The authors conclude the review with a list of the most promising areas of development in this field of molecular medicine and biotechnology, including combinations of direct cytotoxic action, immunomodulation, impact on tumor vessels (1), and combination of diagnostic component with facilitating the detection of tumor cells well-known as teranostics.

URL: http://ejournal8.com/journals_n/1585934776.pdf
Number of views: 557      Download in PDF

2. Sofia Borsali, Rabah Chadli
Contribution to the Toxicological Study of the Brown Alga Cystoseira Stricta by Shrimp Brine Test

European Journal of Molecular Biotechnology, 2019, 7(2): 63-72.
DOI: 10.13187/ejmb.2019.2.63CrossRef

This study examines the eco-toxicological assessment of brown algae contamination in the western Mediterranean coast of Algeria at beach of Sidi Ladjal, Wilaya Mostaganem. The toxicity of Cystoseira stricta forests has been estimated in Shrimp Brine (Artemia salina), LD50 lethality tests are widely used in research and applied toxicology; The responses to cyto-toxicity tests on algal extracts by solvents using a standardized method of Brine Shrimp are based on different concentrations. The LD50 values of the different extracts are obtained by different linear expressions. The results indicate that the raw extracts of the brown seaweed Cystoseira stricta samples from Sidi Ladjel beach are toxic to Artemia salina, These extracts gave different results for each concentration subjected to brine and the percentage of larval mortality increases with concentration. According to different Toxicity Assessment Criteria we were able to conclude that: The most toxic are those of chloroform and petroleum ether where ever Methanol and hexane extracts that are moderately toxic. The study of the antioxidant power by the trapping of the radical DPPH, and the quantification of the total antioxidant capacity, reveals the presence of antioxidant properties for the studied extract; Also regarding the metal contamination, our alga has higher levels of zinc followed by copper and lead. All these results obtained are only a first steep in the search for biologically active natural substances from marine algae.

URL: http://ejournal8.com/journals_n/1585934867.pdf
Number of views: 529      Download in PDF

3. Maha Mobark Gomaa
Novel Simple Cyanine, Carbocyanine, and Dicarbocyanine Dyes: Synthesis, Characterization and Application on Polyester Fabric

European Journal of Molecular Biotechnology, 2019, 7(2): 73-85.
DOI: 10.13187/ejmb.2019.2.73CrossRef

Novel simple cyanine dyes, carbocyanine dyes and dicarbocyanine dyes derived from the nucleus 6-amino-3-methyl-1,2 diaza 4,13 dihydronaphthacene 5, 7, 12 trione (2) were prepared. The electronic visible absorption spectra of all the novel synthesized cyanine dyes were investigated in 95 % ethanol to evaluate their photosensitization characters and uses these dyes as photographic sensitizers in industry. The antimicrobial activity evaluation of mono, tri and pentamethine cyanine dyes against some bacterial and fungi strains( Escherichia coli, Staphylococcus aures, Aspergillus lavus and Candida albicans) was tested. The antimicrobial activity of the dyes usually increases when they give higher inhibition zone diameter against the tested bacterial and fungi strains. The dyeing process and fastness properities of the new synthesized cyanine dyes were examined on polyester fabric. Polyester is the hydrophobic fibres and usually dyed with cyanine dyes due to their high tinctorial strength and good fastness properties. The structural characterization of dyes carried out by elemental analysis, visible, mass spectroscopy, 1H NMR and IR spectra.

URL: http://ejournal8.com/journals_n/1585934924.pdf
Number of views: 552      Download in PDF

4. Ignat Ignatov
Spectral Analyses of Water ADVA. Biophysical, Biochemical and Biological Effects

European Journal of Molecular Biotechnology, 2019, 7(2): 86-90.
DOI: 10.13187/ejmb.2019.2.86CrossRef

Studies were performed with water ADVA. The analyses have been conducted with Nonequilibrium Energy Spectrum (NES) and Differential Nonequilibrium Energy Spectrum (DNES) methods (Antonov, 1995; Ignatov, 1998). Increasing of DNES spectrum of water ADVA according to the control sample was observed. The NES and DNES spectrum were in the range (-0.08 – -0.14 eV) (8.9 –15.5 μm) (645–1129 cm-1). The parameters of the following local extremums were studied: E=-0.1112 eV )(λ=11.15 μm)(ṽ=897 cm-1) is the local extremum for stimulating effect on nervous system and improvement of nervous conductivity. E=-0.1212 eV (λ=10.23 μm)( ṽ=978 cm-1) is the local extremum for anti inflammatory effect. E= -0.1387 eV )(λ=8.95 μm)(ṽ=1117 cm-1) is the local extremum for inhibition of development of tumor cells of molecular level.

URL: http://ejournal8.com/journals_n/1585934981.pdf
Number of views: 530      Download in PDF

5. Z. Jalil, M. El idrissi, A. Barhoumi, A. Zeroual, M. Mbarki, A. Tounsi
The Use of the Parr Function Would Include the Reactivity of the Carbenes with β-himachalene

European Journal of Molecular Biotechnology, 2019, 7(2): 91-99.
DOI: 10.13187/ejmb.2019.2.91CrossRef

Cyclopropanes are molecules of great importance since they are present in several biologically active molecules in addition to being powerful intermediates in the synthesis of complex molecules. During this work, we have étudiéla régio-selectivity of the reactions of cycloaddition [1+2] of the carbènes and ß-himachalènepar the method D.F.T at the level of the base(basis) 6-31 (d), one using a new descriptor of the régio-selectivity it is the function(office) of Parr, we notice according to this study that the attack of a mole of carbènes is preferentially made at the level of the connection C6=C7 of ß-himachalène of in both possibilities of carbènes (nucléophile or électrophile). We also notice that the interaction enters orbital borders of reactives (ß-himachalène-carbènes) is made in a facial way, we also notice that the differences of électrophile Δω (Between carbènes: { CH(CH3), :CCl(Ph), :CH(Ph), :CCl(CH3), :CHF, :CF(Ph), :CF(Cl), :CF2, :C(Ph)2, :CH2, :CHCl, :CCl2, et :C(Br)2} and β-himachalene)varies from 0.162 eV to 3.408 eV; This shows that all reactions studied have a polar character, unlike reactions using alkoxycarbenes and silane-carbene {:ccl(OCH3), CF(OCH3), :C(OCH3)2, :C(OH)2 and:CH(SiH3). } have a non-polar character because Δω is less than 1 (Δω<1).

URL: http://ejournal8.com/journals_n/1585936179.pdf
Number of views: 566      Download in PDF

6. Valery V. Novochadov, Elena A. Ivantsova, Nikolay V. Onistratenko, Pavel A. Krylov
Composition for Targeted Plant Root Treatment in Drylands: Justification of Components and Concentrations for Field Tests

European Journal of Molecular Biotechnology, 2019, 7(2): 100-108.
DOI: 10.13187/ejmb.2019.2.100CrossRef

The study deals with the problem of combating the growth of undesirable vegetation on the borders of agroecosystems and in unrecoverable areas (intrusions) within these systems. The immediate objective of the study was to reduce the growth of dominant and subdominant species in arid plant communities on the example of Artemisia lerchiana. To solve this problem, we used an approach based on the impact on the irremediable or difficultly eliminated herbaceous areas using plant root treatment in the early vegetative phase. To do this, we developed an aqueous suspension of the original variable composition, which provided delivery to the plant roots, based on 1 kg of surface soil layer: 20-40 mg of copper ions and/or 1-2 mg of zinc ions (1); 8-20 mg of citric and/or succinic acid, permissible in the form of sodium or potassium salts (2); and 10-20 mg of chitosan (3). As a result, a complex biogenic effect of the received suspension on the soil microbiota and plants was achieved. The improved inhibiting the plant growth and reducing the projective coverage (only for zinc ions or combination copper with chitosan in high concentrations), are the experimental basis for subsequent field tests. For this study we developed a working algorithm for the selection of components and its concentration, based on mathematical modeling of different responses of plant communities to variations in the composition of the suspension for plant root treatment.

URL: http://ejournal8.com/journals_n/1585935165.pdf
Number of views: 524      Download in PDF

7. H.A. Shindy
Different Methods in the Synthesis of Polyheterocyclic Cyanine Dyes: A Review

European Journal of Molecular Biotechnology, 2019, 7(2): 109-122.
DOI: 10.13187/ejmb.2019.2.109CrossRef

In this paper review different methods in the synthesis of polyheterocyclic cyanine dyes have been reviewed. In this paper review detailed synthesis steps for the synthesis of some polyheterocyclic cyanine dyes were represented via equations. The synthesis covers polyheterocyclic monomethine cyanine dyes (simple cyanine dyes), dimethine cyanine dyes, trimethine cyanine dyes (carbocyanine dyes), tetramethine cyanine dyes, pentamethine cyanine dyes (dicarbocyanine dyes), aza-methine cyanine dyes, hemicyanine dyes (styryl cyanine dyes), merocyanine dyes (acyclic merocyanine dyes and cyclic merocyanine dyes). Besides, in the introduction section of this paper review some light is focused on the some recent applications of cyanine dyes. This review paper is very readable, informative, and useful for synthetic dye chemists, researchers and students who looks for the different methods in the synthesis and preparation of various classes of polyheterocyclic cyanine dyes. In addition, this paper review can be used and/or will be most valuable as a thesis and/or as a note book for student lectures, particularly for the post graduate students and researchers in the field of heterocyclic and/or cyanine dyes chemistry. This specific type of collective review in the different methods in the synthesis of only polyheterocyclic cyanine dyes has been paid little attention and is lacking in the chemistry literature.

URL: http://ejournal8.com/journals_n/1586199759.pdf
Number of views: 537      Download in PDF

Letters to the Editorial

8. Stoil Karadzhov, Ignat Ignatov, Hristo Najdenski, Teodora Popova, Wolfgang Luepcke, Georgi Gluhchev, Nik Kolev, Stefan Balabanov
Distribution Trends of African Swine Fever Virus (ASFV) through Water

European Journal of Molecular Biotechnology, 2019, 7(2): 123-125.
DOI: 10.13187/ejmb.2019.2.123CrossRef

The places for spreading of viruses in ground water are mostly in non-porous media aquifers. They are karst (limestone) aquifers and fractured bedrock (metamorphic rock) (Fong et al., 2007). Different authors have proved the spreading of the viruses in ground water. The Berger’s study has dealt with Enteric virus (Berger, 2007). Norwalk-like virus has detected in ground water (Anderson, 2001). The African swine fever (ASF) is contagious and rapidly spreading swine disease. The great virulence and continuous resilience in the environment, including in the natural water sources as an activator of African swine fever virus (ASFV), are a prerequisite for a seamless cross-border transmission of the disease, defining it as a main threat for the world’s pig meat production. In 2007 ASFV infected pigs in Georgia, and in 2014 it reached the European Union (Boklund et al., 2018). In 2019 it has been observed in Bulgaria and has had serious economic consequences. The Tissue Culture Infectious Dose (TCID) for pigs is 101.0 TCID50 in liquids, and is 106.8 TCID50 in dried fodder (Niederwerder et al., 2019). Contaminated water from the Danube River has been implicated in introducing ASF onto the ≈140,000 pig-breeding farms.

URL: http://ejournal8.com/journals_n/1585935512.pdf
Number of views: 543      Download in PDF

full number
URL: http://ejournal8.com/journals_n/1586199770.pdf
Number of views: 571      Download in PDF

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